Home
Products
Stattic
| Product Name | Stattic |
| Price: | Inquiry |
| Catalog No.: | CN00435 |
| CAS No.: | 19983-44-9 |
| Molecular Formula: | C8H5NO4S |
| Molecular Weight: | 211.19 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | [O-][N+](=O)c1ccc2c(c1)S(=O)(=O)C=C2 |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Stattic is a potent inhibitor of STAT3 activation and dimerization. |
| Target | STAT3 |
| In Vitro | Stattic inhibits STAT3 phosphorylation (Y705) in ALDH+ and D44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cell lines at a higher concenration (20 μM). Stattic selectively inhibits P-STAT3 as demonstrated by the lack of inhibition of P-ERK1/2 in both ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC. Stattic inhibita STAT3 downstream targets in ALDH+ and CD44+/CD24+ subpopulations of pancreatic cancer cells[1]. Stattic reduces the LPS-induced expression of ICAM-1 and VCAM-1, and STAT3 phosphorylation[2]. |
| Cell Assay | Pancreatic cancer stem-like cells (3,000/well in 96-well plates) are incubated with desired concentrations of compounds in triplicate at 37˚C for 72 h. MTT viability assays are done and the absorbance is read at 595 nm. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 461.1±45.0 °C at 760 mmHg |
| Flash Point | 232.6±28.7 °C |
| Exact Mass | 210.993927 |
| PSA | 88.34000 |
| LogP | 1.31 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Storage condition | Store at +4°C |