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Lucidone
| Product Name | Lucidone |
| Price: | Inquiry |
| Catalog No.: | CN05693 |
| CAS No.: | 19956-53-7 |
| Molecular Formula: | C15H12O4 |
| Molecular Weight: | 256.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Lindera strychnifolia |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2]. |
| Target | p38 MAPK JNK p50 p65 COX-2 NF-κB iNOS IKK |
| In Vitro | Lucidone (10 μg/mL, 25 μg/mL; 1 h 或 20 h) 降低 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致 TNF-α 分泌 (20 h) 以及 PGE2 产量 (1 h) 的增加[1]。 Lucidone (10 μg/mL, 25 μg/mL; 8 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 iNOS 和 COX-2 表达的增加[1]。 Lucidone (10 μg/mL, 25 μg/mL; 1 h) 抑制 RAW 264.7 巨噬细胞受 LPS (1 μg/mL) 诱导而导致的 NF-κB p65/p50 水平的增加，以及 IKK 蛋白的磷酸化[1]。 Lucidone (0-40 μM; 3 d) 降低感染 Huh-7 细胞中 DENV 的病毒滴度[2]。 Western Blot Analysis[1] Cell Line: RAW 264.7 macrophages Concentration: 5 μg/mL, 10 μg/mL, 25 μg/mL Incubation Time: 1 hour Result: Inhibited LPS-induced NF-κB nuclear translocation, decreased the level of p65 and of the p50 subunits at 10 μg/mL and 25 μg/mL. Inhibited the phosphorylation of IKK at 10 μg/mL and 25 μg/mL. Cell Viability Assay[2] Cell Line: Huh-7 cells infected with DENV Concentration: 5 μM, 10 μM, 20 μM, and 40 μM Incubation Time: 3 days Result: Showed no significant cell viability on Huh-7 cells, while leading to a decrease on viral load of DENV. |
| In Vivo | Lucidone (1 mg/kg; 颅内注射; 一周内 3 次) 显著提高 DENV 感染小鼠的存活率和体重[2]。 Animal Model: DENV-infected ICR mice[2] Dosage: 0.4 mg/kg, 1 mg/kg Administration: Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection Result: Increased the survival rate and body weight of DENV-infected mice on day 7. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 489.6±45.0 °C at 760 mmHg |
| Flash Point | 188.6±22.2 °C |
| Exact Mass | 256.073547 |
| PSA | 63.60000 |
| LogP | 1.95 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Storage condition | 2-8℃ |