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Bavachinin
| Product Name | Bavachinin |
| Price: | $46 / 20mg |
| Catalog No.: | CN05465 |
| CAS No.: | 19879-30-2 |
| Molecular Formula: | C21H22O4 |
| Molecular Weight: | 338.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The seeds of Psoralea corylifolia L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc2O[C@@H](CC(=O)c2cc1CC=C(C)C)c1ccc(cc1)O |
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| Description | Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent anti-angiogenic activity.IC50 value:Target:in vitro: Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Aβ42-induced toxicity in a SH-SY5Y cell model [1]. Bavachinin, has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α [2].in vivo: significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model [3]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 537.1±50.0 °C at 760 mmHg |
| Flash Point | 190.3±23.6 °C |
| Exact Mass | 338.151794 |
| PSA | 55.76000 |
| LogP | 4.93 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Storage condition | ?20°C |