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Cardamonin
| Product Name | Cardamonin |
| Price: | $31 / 20mg |
| Catalog No.: | CN05695 |
| CAS No.: | 19309-14-9 |
| Molecular Formula: | C16H14O4 |
| Molecular Weight: | 270.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The seeds of Alpinia katsumadai Hayata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(O)cc(c1C(=O)/C=C/c1ccccc1)O |
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| Description | Cardamonin is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM. |
| Target | IC50: 454 nM (hTRPA1 cation channel)[1] |
| In Vitro | Cardamonin selectively blocksTRPA1 activation (IC50=454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. Cardamonin does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction[1]. Cardamonin suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells[2]. |
| In Vivo | Cardamonin (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia[2]. |
| Cell Assay | HEK293 cells are treated with cardamonin (0-90 μM). The cells treated in the absence of the test compound are the negative control. After incubated for 24 h, Cell Titer-Glo reagent is added to the cells and Luminescence is acquired on the plate reader[1]. |
| Animal Admin | Rats: The rats are divided into groups of six according to their nociceptive pressure thresholds, after which carrageenan (0.1 mL, 1%) is injected into the plantar surface of the left hind paw. The rats received vehicle or cardamonin (3-30 mg/kg) or indomethacin (3 mg/kg) orally 2 h after carrageenan injection and are evaluated for paw hyperalgesia 0, 1 and 2 h after administration of compounds. Indomethacin is used as a positive control[2]. Mice: Acute pain is induced by an intraperitoneal injection of 0.2 mL of 0.02% PBQ 54 min after oral administration of cardamonin. Six minutes after the PBQ injection, the total number of writhes is counted for 6 min. The control animals received an appropriate volume of dosing vehicle (80% saline, 10% ethanol and 10% Tween 80). Indomethacin is used as a positive control[2]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 484.5±45.0 °C at 760 mmHg |
| Flash Point | 182.7±22.2 °C |
| Exact Mass | 270.089203 |
| PSA | 66.76000 |
| LogP | 3.62 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Storage condition | Store at +4°C |