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Cudraflavone B
| Product Name | Cudraflavone B |
| Price: | Inquiry |
| Catalog No.: | CN04592 |
| CAS No.: | 19275-49-1 |
| Molecular Formula: | C25H24O6 |
| Molecular Weight: | 420.45 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Cudrania tricuspidata |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells[1][2]. |
| Target | NF-κB COX-2 COX-1 TNFRSF1A p38 MAP kinase ERK SIRT1 |
| Exact Mass | 420.15700 |
| PSA | 100.13000 |
| LogP | 5.26970 |