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Wistin
| Product Name | Wistin |
| Price: | Inquiry |
| Catalog No.: | CN04163 |
| CAS No.: | 19046-26-5 |
| Molecular Formula: | C23H24O10 |
| Molecular Weight: | 460.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The aerial parts of Ammopiptanthus mongolicus |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist[1][2]. |
| In Vitro | Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2]. Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2]. Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2]. Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2]. Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3]. RT-PCR[2] Cell Line: Mouse hepatocytes. Concentration: 1 or 10 μg/mL. Incubation Time: 48 h. Result: Significantly increased PPARα mRNA levels in a dose-dependent manner. |
| Exact Mass | 460.13700 |
| PSA | 148.05000 |
| LogP | 0.65590 |