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Lactucin
| Product Name | Lactucin |
| Price: | $263 / 10mg |
| Catalog No.: | CN08991 |
| CAS No.: | 1891-29-8 |
| Molecular Formula: | C15H16O5 |
| Molecular Weight: | 276.28 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Lactuca virosa |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4]. |
| In Vitro | Lactucin shows moderate inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages[1]. Lactucin (0-100 µM, 24 and 48 h) induces cytotoxic effects in HL-60 cells in a dose– and time-dependent manner[3]. Lactucin (0-100 µM, 48 h) induces apoptosis and sub-G1 cell cycle arrest in HL-60 cells[3]. Lactucin (10 μg/mL, 48 h) completely prevents Plasmodium falciparum parasitemia[4]. Cell Viability Assay[3] Cell Line: HL-60 Concentration: 0, 5, 25, 50, and 100 µM Incubation Time: 24 and 48 h Result: Induced significant cytotoxic effects in these cancer cells in a dose– and time-dependent manner. Apoptosis Analysis[3] Cell Line: HL-60 Concentration: 0, 5, 50 and 100 µM Incubation Time: 48 h Result: Induced apoptosis. Swelling of the mitochondria and endoplasmic reticulum (ER) was detected in the cells. Cell Cycle Analysis[3] Cell Line: HL-60 Concentration: 0, 5, 50 and 100 µM Incubation Time: 48 h Result: Induced sub-G1 cell cycle arrest. |
| In Vivo | Lactucin (15 and 30 mg/kg; i.p.; once) decreases the spontaneous locomotor activity and shows analgesic properties in mice[2]. Animal Model: Male Albino-Swiss mice (18-24 g)[2] Dosage: 15 and 30 mg/kg Administration: Intraperitoneal injection, once Result: Decreased the spontaneous locomotor activity and showed analgesic properties in the hot plate test. |
| Exact Mass | 276.10000 |
| PSA | 83.83000 |
| LogP | 0.28290 |
| Vapour Pressure | 1.2E-15mmHg at 25°C |