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Paederosidic acid
| Product Name | Paederosidic acid |
| Price: | $131 / 10mg |
| Catalog No.: | CN03101 |
| CAS No.: | 18842-98-3 |
| Molecular Formula: | C18H24O12S |
| Molecular Weight: | 464.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Iridoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Paederia scandens (Lour.) Merr |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@@H](O[C@@H]2OC=C([C@@H]3[C@H]2C(=C[C@@H]3O)COC(=O)SC)C(=O)O)[C@@H]([C@H]([C@@H]1O)O)O |
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| Description | Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1]. |
| Target | IC50: apoptosis[1] |
| In Vitro | Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of 40.68, 42.58, and 36.48 μg/ml, respectively[1]. Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells[1]. . |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 748.1±70.0 °C at 760 mmHg |
| Flash Point | 406.2±35.7 °C |
| Exact Mass | 464.098846 |
| PSA | 217.74000 |
| LogP | -1.48 |
| Vapour Pressure | 0.0±5.6 mmHg at 25°C |