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Psoralidin
| Product Name | Psoralidin |
| Price: | $62 / 20mg |
| Catalog No.: | CN06253 |
| CAS No.: | 18642-23-4 |
| Molecular Formula: | C20H16O5 |
| Molecular Weight: | 336.34 g/mol |
| Purity: | >=98% |
| Type of Compound: | Coumarins |
| Physical Desc.: | Powder |
| Source: | The seeds of Psoralea corylifolia. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=CCc1cc2c(cc1O)oc(=O)c1c2oc2c1ccc(c2)O)C |
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| Description | Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. possessing anti-cancer properties.IC50 value:Target: Anticancer natural compoundin vitro: PSO dramatically decreased the cell viabilities in dose- and time-dependent manner. Autophagy inhibitor 3-MA blocked the production of LC3-II and reduced the cytotoxicity in response to PSO. Furthermore, PSO increased intracellular ROS level which was correlated to the elevation of LC3-II [1]. Psoralidin at 10 μM was able to induce the maximum reporter gene expression corresponding to that of E2-treated cells and such activation of the ERE-reporter gene by psoralidin was completely abolished by the cotreatment of a pure ER antagonist, implying that the biological activities of psoralidin are mediated by ER [2]. Psoralidin enhanced TRAIL-induced apoptosis in HeLa cells through increased expression of TRAIL-R2 death receptor and depolarization of mitochondrial membrane potential [3]. Psoralidin inhibited the IR-induced COX-2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. Also, psoralidin blocked IR-induced LTB(4) production, and it was due to direct interaction of psoralidin and 5-lipoxygenase activating protein (FLAP) in 5-LOX pathway. IR-induced fibroblast migration was notably attenuated in the presence of psoralidin [4].in vivo: Moreover, in vivo results from mouse lung indicate that psoralidin suppresses IR-induced expression of pro-inflammatory cytokines (TNF-α, TGF-β, IL-6 and IL-1 α/β) and ICAM-1[4]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 458.8±34.0 °C at 760 mmHg |
| Flash Point | 231.3±25.7 °C |
| Exact Mass | 336.099762 |
| PSA | 83.81000 |
| LogP | 5.03 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Storage condition | ?20°C |