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Crotonoside
| Product Name | Crotonoside |
| Price: | $103 / 20mg |
| Catalog No.: | CN02193 |
| CAS No.: | 1818-71-9 |
| Molecular Formula: | C10H13N5O5 |
| Molecular Weight: | 283.24 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The seeds of Croton tiglium L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1[nH]c(=O)nc2N |
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| Description | Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML[1]. |
| Target | FLT3 HDAC3 HDAC6 |
| In Vitro | Crotonoside (0-200 μM;) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively[1]. Crotonoside (0-100μM; 7 hours) inhibits the phosphorylation of FLT3 Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner[1]. Crotonoside (0-100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells[1]. Crotonoside (0-100 μM; 24 hours) leads to concentration-dependent changes in the number of apoptotic MV4-11 cells, results in a dose-dependent decrease in the level of pro-caspase-3 and a dose-dependent increase in the level of the cleaved caspase-3 fragments[1]. Cell Viability Assay[1] Cell Line: AML cell line MV4-11, MOLM-13 and KG-1 cells Concentration: 0-200 μM Incubation Time: 72 hours Result: Inhibited AML cells growth than other cell lines tested. Western Blot Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 7 hours Result: Inhibited AML cells growth than other cell lines tested. Cell Cycle Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 12 hours Result: Induced cell cycle arrest in G0/G1. Apoptosis Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 24 hours Result: Induced MV4-11 cell apoptosis. |
| In Vivo | Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle[1]. Animal Model: NOD-SCID mice with MV4-11 cells[1] Dosage: 70 mg/kg, 35 mg/kg Administration: Intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily Result: Produced significant AML tumor inhibition rates of 93.5% at 70 mg/kg. |
| Density | 2.3±0.1 g/cm3 |
| Boiling Point | 831ºC at 760 mmHg |
| Flash Point | 456.4ºC |
| Exact Mass | 283.091675 |
| PSA | 159.51000 |
| LogP | -3.42 |
| Vapour Pressure | 2.83E-29mmHg at 25°C |