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4,5-Dimethoxycanthin-6-one
| Product Name | 4,5-Dimethoxycanthin-6-one |
| Price: | $161 / 10mg |
| Catalog No.: | CN02144 |
| CAS No.: | 18110-87-7 |
| Molecular Formula: | C16H12N2O3 |
| Molecular Weight: | 280.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Yellow powder |
| Source: | The barks of Picrasma quassioides (D.Don) Benn |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2]. |
| Target | CYP1A2:1.7 μM (IC50) CYP1A2:2.6 μM (Ki) |
| In Vitro | 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM[2]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 455.1±45.0 °C at 760 mmHg |
| Flash Point | 229.0±28.7 °C |
| Exact Mass | 280.084778 |
| PSA | 52.83000 |
| LogP | 2.16 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |