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Curzerene
| Product Name | Curzerene |
| Price: | $114 / 20mg |
| Catalog No.: | CN09374 |
| CAS No.: | 17910-09-7 |
| Molecular Formula: | C15H20O |
| Molecular Weight: | 216.32 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Oil |
| Source: | The rhizomes of Curcuma zedoaria. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1]. |
| Target | GSTA1[1] |
| In Vitro | Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1]. Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1]. Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1]. Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1]. Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 24 hours, 48 hours, 72 hours Result: Inhibited growth of non-small cell lung cancer SPC A1 cells in vitro. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced apoptosis of the cells in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: SPC-A1 cells Concentration: 0 µM, 6.25 µM, 12.5 µM, 25 µM, 50 µM, 100 µM Incubation Time: 48 hours Result: Induced G2/M cell cycle arrest of SPC A1 cells. RT-PCR[1] Cell Line: SPC-A1 cells Concentration: 6.25 µM, 25 µM, 100 µM Incubation Time: 48 hours Result: Decreased GSTA1 mRNA expression. |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 282.8±40.0 °C at 760 mmHg |
| Flash Point | 117.5±14.2 °C |
| Exact Mass | 216.151413 |
| PSA | 13.14000 |
| LogP | 5.78 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Storage condition | 2-8℃ |