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2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
| Product Name | 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid |
| Price: | Inquiry |
| Catalog No.: | CN07421 |
| CAS No.: | 176983-21-4 |
| Molecular Formula: | C30H46O5 |
| Molecular Weight: | 486.69 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The leaves of Eriobotrya japonica. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV Protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells[1][2]. |
| In Vitro | 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid (0.01-0.1 μM) 在脂多糖激活的巨噬细胞系、RAW 264.7 细胞中显示出对一氧化氮产生的中等抑制活性[1 ]。 |
| In Vivo | 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid (0.0025%；饮用水；20 周) 显示出对 TPA 诱导的 EBV-EA 激活的抑制作用，并导致显着延迟 小鼠皮肤两阶段癌变[2]。 Animal Model: Female ICR mice (6 weeks old)[2] Dosage: 0.0025% Administration: Drinking water; for 20 weeks Result: Showed an inhibitory effect on the activation of EBV-EA induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 616.9±55.0 °C at 760 mmHg |
| Flash Point | 340.9±28.0 °C |
| Exact Mass | 486.334534 |
| LogP | 5.45 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Storage condition | 2-8℃ |