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Fucosterol
| Product Name | Fucosterol |
| Price: | $131 / 20mg |
| Catalog No.: | CN02346 |
| CAS No.: | 17605-67-3 |
| Molecular Formula: | C29H48O |
| Molecular Weight: | 412.69 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The herbs of Undaria pinnatifida |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C=C(/C(C)C)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC=C2[C@]1(C)CC[C@@H](C2)O)C |
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| Description | Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression. |
| Target | PPARα; C/EBPα[1] |
| In Vitro | Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1].Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3]. Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. Cell Viability Assay[1] Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression. |
| In Vivo | Fucosterol (orally adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2]. |
| Density | 0.98 g/cm3 |
| Boiling Point | 504.2ºC at 760 mmHg |
| Flash Point | 220.3ºC |
| Exact Mass | 412.37100 |
| PSA | 20.23000 |
| LogP | 7.94490 |
| Vapour Pressure | 2.8E-12mmHg at 25°C |
| Storage condition | 2-8°C |