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Brevilin A
| Product Name | Brevilin A |
| Price: | $117 / 10mg |
| Catalog No.: | CN09505 |
| CAS No.: | 16503-32-5 |
| Molecular Formula: | C20H26O5 |
| Molecular Weight: | 346.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Centipeda minima |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C/C=C(C(=O)O[C@H]1[C@H]2[C@@H](C[C@H]([C@H]3[C@@]1(C)C(=O)C=C3)C)OC(=O)[C@H]2C)/C |
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| Description | Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2]. |
| Target | IC50: 10.6 µM (STAT3 signaling)[1] |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 494.0±45.0 °C at 760 mmHg |
| Flash Point | 216.0±28.8 °C |
| Exact Mass | 346.178009 |
| PSA | 69.67000 |
| LogP | 2.98 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |