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6-Deoxyjacareubin
| Product Name | 6-Deoxyjacareubin |
| Price: | Inquiry |
| Catalog No.: | CN05771 |
| CAS No.: | 16265-56-8 |
| Molecular Formula: | C18H14O5 |
| Molecular Weight: | 310.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Xanthones |
| Physical Desc.: | Yellow powder |
| Source: | The stems and roots of Hypericum brasiliense. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | 6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS)[1]. |
| In Vitro | 6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。 |
| In Vivo | 6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice[1]. Animal Model: Male SOD1G93A mice (eight weeks)[1] Dosage: 5 mg/kg Administration: Intraperitoneally (i.p.), every seven days for 1 month Result: Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 523.4±50.0 °C at 760 mmHg |
| Flash Point | 195.8±23.6 °C |
| Exact Mass | 310.084137 |
| PSA | 79.90000 |
| LogP | 3.99 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |