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Escin IIB
| Product Name | Escin IIB |
| Price: | Inquiry |
| Catalog No.: | CN07326 |
| CAS No.: | 158800-83-0 |
| Molecular Formula: | C54H84O23 |
| Molecular Weight: | 1101.24 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Aesculus hippocastanum L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals[1]. Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions[2]. |
| In Vivo | Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibit the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1]. Escin IIb (10-50 mg/kg; p.o.) potently inhibits ethanol-induced gastric mucosal lesions[2]. Animal Model: Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[2] Dosage: P.o. Administration: 10-50 mg/kg Result: Showed a potent protective effect against ethanol-induced gastric lesions in rats. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 1111.9±65.0 °C at 760 mmHg |
| Flash Point | 305.5±27.8 °C |
| Exact Mass | 1100.540283 |
| LogP | 4.87 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |