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Harzianic acid
| Product Name | Harzianic acid |
| Price: | Inquiry |
| Catalog No.: | CN01826 |
| CAS No.: | 157148-06-6 |
| Molecular Formula: | C19H27NO6 |
| Molecular Weight: | 365.42 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The branches of Broussonetia papyrifera |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2]. |
| Target | Acetohydroxyacid synthase (AHAS)[2] |
| In Vitro | Harzianic acid 对 MRSP 和 MSSP 表现出较强的抑菌活性，MIC 值分别为 32 μg/mL 和 16 μg/mL [1]。 Harzianic acid (8-128 μg/mL) 对 HaCaT 细胞毒性较低[1]。 Harzianic acid 作为一种竞争性抑制剂抑制真菌 ThAHAS, Ki 为 6.65 μM[2]。 Harzianic acid (0.1-100 μg/mL) 对病原真菌的生长有抑制作用[2]。 |
| Density | 1.233g/cm3 |
| Boiling Point | 539.8ºC at 760mmHg |
| Flash Point | 280.3ºC |
| Exact Mass | 365.18400 |
| PSA | 115.14000 |
| LogP | 1.92040 |
| Vapour Pressure | 6.63E-14mmHg at 25°C |