Home
Products
4-Hydroxyphenylacetic acid
| Product Name | 4-Hydroxyphenylacetic acid |
| Price: | $12 / 20mg |
| Catalog No.: | CN03787 |
| CAS No.: | 156-38-7 |
| Molecular Formula: | C8H8O3 |
| Molecular Weight: | 152.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Bulbophyllum odoratissimum. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OC(=O)Cc1ccc(cc1)O |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1]. |
| Target | Nrf2[1] |
| In Vivo | 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 346.6±17.0 °C at 760 mmHg |
| Flash Point | 177.6±17.4 °C |
| Exact Mass | 152.047348 |
| PSA | 57.53000 |
| LogP | 0.77 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |