Home
Products
7alpha,15-Dihydroxydehydroabietic acid
| Product Name | 7alpha,15-Dihydroxydehydroabietic acid |
| Price: | Inquiry |
| Catalog No.: | CN08291 |
| CAS No.: | 155205-64-4 |
| Molecular Formula: | C20H28O4 |
| Molecular Weight: | 332.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The caulis and leaves of Callicarpa kochiana. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | 7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1]. |
| In Vitro | 7α,15-Dihydroxydehydroabietic acid（3.125-100 μM；24 小时）显着降低 HUVEC 细胞活力[1]。 7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 小时) 显着抑制 HUVEC 中血管生成的促进作用。7α,15-Dihydroxydehydroabietic acid 通过下调 VEGF、p-Akt 和 p-ERK 信号通路抑制血管生成[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Significantly decreased HUVEC cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM Incubation Time: 24 hours Result: Human umbilical vein endothelial cells (HUVECs)[1]3.125 μM, 6.25 μM24 hoursShowed downregulation of VEGF, p-Akt and p-ERK in HUVECs. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 511.4±50.0 °C at 760 mmHg |
| Flash Point | 277.2±26.6 °C |
| Exact Mass | 332.198761 |
| LogP | 2.84 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |