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Cimiside E
| Product Name | Cimiside E |
| Price: | Inquiry |
| Catalog No.: | CN07354 |
| CAS No.: | 154822-57-8 |
| Molecular Formula: | C35H54O8 |
| Molecular Weight: | 602.80 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The herbs of Cimicifuga foetida |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Cimiside E (25-Anhydrocimigenol xyloside) is a triterpene xyloside, Cimiside E possesses apoptotic action on gastric cancer cells, with an IC50 value of 14.58 μM. Cimiside E induces cell cycle arrest at G2/M phase, and mediates apoptosis through the induction of the Caspase cascade for both the extrinsic and intrinsic pathways[1][2]. |
| Target | Caspase 3 |
| In Vitro | Cimiside E (30-90 μM; 24 h) 阻滞细胞周期，诱导 ASG 细胞凋亡[1]。 Cimiside E (30-90 μM; 12-48 h) 对 AGS 细胞有较强的细胞毒性，并表现出抗增殖活性[1]。 Cimiside E (15-60 μM; 6-24 h) 诱导 ASG细胞中 DNA 片段化，(30-60 μM; 1-6 h) 并在 3 h 时激活 FasL 的表达，在 1 h 激活 Fas[1]。 Cimiside E (30-90 μM; 3-24 h) 介导 caspase 级联，增加 Bax/Bcl-2 比值，降低突变型 p53 和 procaspase 3 蛋白水平[1]。 Western Blot Analysis[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 3 h, 6 h, 12 h, and 24 h Result: Increased the ratio of Bax/Bcl-2 expression from 60 μM. Decreased mutant type (mt) p53 levle from 12 h at 30 µM. Suppressed the protein level of procaspase 3 in a dose-dependent manner from 30 μM. Cell Proliferation Assay[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 12 h, 24 h, and 48 h Result: Inhibited ASG cells proliferation with IC50s of 28.7, 14.6 and 8.1 µM, respectively, for 30 μM, 60 μM, and 90 μM treatment. Cell Cycle Analysis[1] Cell Line: Cimiside E. AGS cells Concentration: 30 μM, 60 μM, and 90 μM Incubation Time: 3 h, 6 h, and 24 h Result: Induced cell cycle arrest at S phase in a low concentration (30 μM), but arrested cell cycle at G2/M phase in higher concentration (60 μM and 90 μM). |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 723.8±60.0 °C at 760 mmHg |
| Flash Point | 391.6±32.9 °C |
| Exact Mass | 602.381897 |
| LogP | 6.81 |
| Vapour Pressure | 0.0±5.3 mmHg at 25°C |