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Cyclocurcumin
| Product Name | Cyclocurcumin |
| Price: | Inquiry |
| Catalog No.: | CN03436 |
| CAS No.: | 153127-42-5 |
| Molecular Formula: | C21H20O6 |
| Molecular Weight: | 368.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Curcuma longa L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities[1][2][3]. |
| In Vitro | Cyclocurcumin (10-40 μM; 18 h) 导致 LPS 刺激的人巨噬细胞中 TNF-α 释放呈剂量依赖性显著抑制[1]。 Cyclocurcumin (5-25 μM) 对新分离大鼠主动脉环苯肾上腺素 (HY-B0769) 诱导的血管收缩呈浓度依赖性 (IC50=14.9±1.0 μM)[2]。 Cyclocurcumin (5-25 μM; 30 min) 以剂量依赖的方式抑制细胞内钙的内流。Cyclocurcumin 以浓度依赖的方式抑制 l 型钙通道介导的血管收缩。Cyclocurcumin 的抗收缩作用是可逆的[2]。 Cyclocurcumin 具有很强的清除 ˙OH 和 ˙OOH 自由基的活性，其 4 ' -OH 酚自由基通过水中和生理环境中的原子转移机制优先清除 ˙OH 和 ˙OOH 自由基[3]。 |
| Exact Mass | 368.12600 |
| PSA | 85.22000 |
| LogP | 3.74280 |