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Trigothysoid N
| Product Name | Trigothysoid N |
| Price: | Inquiry |
| Catalog No.: | CN08440 |
| CAS No.: | 1501943-08-3 |
| Molecular Formula: | C44H58O13 |
| Molecular Weight: | 794.95 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The twigs and leaves of Trigonostemon thyrsoideum. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Trigothysoid N is a daphnane diterpenoid with anticancer activity. Trigothysoid N inhibits tumor proliferation and migration by targeting mitochondria, regulating the STAT3/FAK signal pathway, and suppressing angiogenesis. Trigothysoid N also induce apoptosis, can be used for research of non-small cell lung cancer (NSCLC)[1]. |
| In Vitro | Trigothysoid N (5、15 和 45 μM；48 小时) 以剂量依赖性方式抑制肿瘤细胞生长[1]。 Trigothysoid N (5、10 和 20 μM；48 小时) 诱导细胞凋亡并使细胞周期停滞在 G0/G1 期[1]。 Trigothysoid N (5、10 和 20 μM；48 小时) 诱导 MMP 去极化，并增加细胞 ROS 的产生，从而刺激 A549 细胞凋亡[1]。 Trigothysoid N 通过线粒体依赖性信号通路诱导细胞凋亡，并通过调节 FAK 信号通路抑制 A549 细胞转移[1]。 Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 5, 10, and 20 μM Incubation Time: 48 h Result: Resulted the apoptotic cell percentages increased from 9.9% (control) to 12.6% (5.0 μM), 15.4% (10.0 μM), and 59.0% (20.0 μM). |
| In Vivo | Trigothysoid N (0.025、0.05 和 0.1 μM; 4 h) 在转基因斑马鱼模型中显示出抗血管生成活性和抗 A549 肿瘤活性[1]。 Animal Model: Transgenic zebrafish model transplanted with CM-DiI-stained A549 cells[1] Dosage: 0.025, 0.05, and 0.1 μM Administration: Result: Inhibited angiogenesis. Disrupted intersegmental blood vessels (ISVs) and dorsal longitudinal anastomotic vessels (DLAVs) in zebrafish. Inhibited tumor cell proliferation with inhibitory rates of 5.7% (0.025 μM), 14.8% (0.05 μM) and 56.9% (0.1 μM), respectively. |
| Density | 1.4±0.1 g/cm3 |
| Exact Mass | 794.387756 |
| LogP | 9.13 |