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Chrysosplenol D
| Product Name | Chrysosplenol D |
| Price: | $497 / 5mg |
| Catalog No.: | CN05515 |
| CAS No.: | 14965-20-9 |
| Molecular Formula: | C18H16O8 |
| Molecular Weight: | 360.3 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Yellow powder |
| Source: | The herbs of Artemisia annua L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1c(oc2c(c1=O)c(O)c(c(c2)OC)OC)c1ccc(c(c1)O)O |
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| Description | Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. |
| In Vitro | Chrysosplenol D inhibits the cell viability of CaCo2 cells, with IC50 of 63.48 μM[1]. Chrysosplenol D (1-100 μM; 48 h) selectively inhibits the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3[2]. Chrysosplenol D (1-10 μM; 48 h) induces cell cycle aberrations with accumulation of cells in the S-phase and partially in the G2/M-phase of the cell cycle[2]. Chrysosplenol D (1-10 μM; 48 h) induce apoptosis in breast cancer cells[2]. Chrysosplenol D shows moderate antitrypanosomal activity, with IC50 of 47.27 μM for T.b. brucei[3]. |
| In Vivo | Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2]. Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4]. Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 645.0±55.0 °C at 760 mmHg |
| Flash Point | 237.3±25.0 °C |
| Exact Mass | 360.084503 |
| PSA | 118.59000 |
| LogP | 2.29 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |