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Yohimbine
| Product Name | Yohimbine |
| Price: | Inquiry |
| Catalog No.: | CN01422 |
| CAS No.: | 146-48-5 |
| Molecular Formula: | C21H26N2O3 |
| Molecular Weight: | 354.44 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Cryst. |
| Source: | The peels of Corynante yohimbe. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 |
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| Description | Yohimbine is a potent and relatively nonselective alpha 2-adrenergicreceptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1]Target: alpha 2-adrenergic receptorin vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, and 1.19 nM for α2A, α2B, α2C, respectively. Yohimbine also inhibits 5-HT1B with Ki of 19.9 nM. Yohimbine acts to block the lowering of cAMP by alpha-2 adrenoceptor agonists. yohimbine actually causes a pronounced lowering of tyrosinase activity. [3]in vivo: Yohimbine is an antagonist at alpha2-noradrenaline receptors with putative panicogenic effects in human subjects, was administered to Swiss-Webster mice at doses of 0.5, 1.0, and 2.0 mg/kg. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.[2] |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 543.0±50.0 °C at 760 mmHg |
| Flash Point | 282.2±30.1 °C |
| Exact Mass | 354.194336 |
| PSA | 65.56000 |
| LogP | 2.20 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Storage condition | Store at RT |