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SH-4-54
| Product Name | SH-4-54 |
| Price: | Inquiry |
| Catalog No.: | CN00445 |
| CAS No.: | 1456632-40-8 |
| Molecular Formula: | C29H27F5N2O5S |
| Molecular Weight: | 610.59 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C(N(c1ccc(cc1)C(=O)O)Cc1ccc(cc1)C1CCCCC1)CN(S(=O)(=O)c1c(F)c(F)c(c(c1F)F)F)C |
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| Description | SH-4-54 is a most potent, small molecule, nonphosphorylated STAT inhibitor, with KDs of 300, 464 nM for STAT3 and STAT5, respectively. |
| Target | STAT3:300 nM (Kd) STAT5:464 nM (Kd) |
| In Vitro | SH-4-54 potently kills glioblastoma brain cancer stem cells (BTSCs) and effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets at low nM concentrations.SH-4-54 shows unprecedented cytotoxicity in human BTSCs, displays no toxicity in human fetal astrocytes, potently suppresses pSTAT3 with nanomolar IC50s, inhibiting STAT3's downstream targets, and shows no discernible off-target effects at therapeutic doses[1]. |
| In Vivo | SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors[1]. |
| Density | 1.431±0.06 g/cm3 |
| Boiling Point | 717.2±70.0 °C at 760 mmHg |
| Flash Point | 387.5±35.7 °C |
| Exact Mass | 610.156067 |
| PSA | 103.37000 |
| LogP | 7.64 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Storage condition | -20℃ |