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Licochalcone C
| Product Name | Licochalcone C |
| Price: | $146 / 5mg |
| Catalog No.: | CN05699 |
| CAS No.: | 144506-14-9 |
| Molecular Formula: | C21H22O4 |
| Molecular Weight: | 338.40 g/mol |
| Purity: | >=98% |
| Type of Compound: | Chalcones |
| Physical Desc.: | Yellow powder |
| Source: | The roots of Glycyrrhiza glabra L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1c(/C=C/C(=O)c2ccc(cc2)O)ccc(c1CC=C(C)C)O |
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| Description | Licochalcone C could inhibit α-glucosidase, with IC50s of <100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively. |
| Target | IC50: <100 nM (α-glucosidase), 92.43 μM (PTP1B)[1]. |
| In Vitro | Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration‑dependent manner. Licochalcone C treatment reduces the levels of the anti‑apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2]. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 536.1±50.0 °C at 760 mmHg |
| Flash Point | 188.4±23.6 °C |
| Exact Mass | 338.151794 |
| PSA | 66.76000 |
| LogP | 5.33 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Storage condition | 2-8C |