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Shizukaol B
| Product Name | Shizukaol B |
| Price: | Inquiry |
| Catalog No.: | CN09231 |
| CAS No.: | 142279-40-1 |
| Molecular Formula: | C40H44O13 |
| Molecular Weight: | 732.77 g/mol |
| Purity: | >=98% |
| Type of Compound: | Sesquiterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Chloranthus japonicus. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1]. |
| Target | COX-2 iNOS IL-1β |
| In Vitro | Shizukaol B (25 μM; 0-60 min) 抑制 LPS (1 μg/mL; 0-60 min) 介导的 c-Jun N 末端激酶 1/2 (JNK) 激活，不影响 ERK1/2 或 p38 磷酸化[1]。 Shizukaol B (12.5-50 μM; 4 h) 抑制 LPS 诱导 (1 μg/mL; 24 h) 的 NO 生成，抑制 iNOS 和 COX-2 的表达[1]。 |
| Exact Mass | 732.27800 |
| PSA | 189.03000 |
| LogP | 2.37710 |