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NMS-873
| Product Name | NMS-873 |
| Price: | Inquiry |
| Catalog No.: | CN00271 |
| CAS No.: | 1418013-75-8 |
| Molecular Formula: | C27H28N4O3S2 |
| Molecular Weight: | 520.67 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Cc1cc(OCc2nnc(n2c2cccnc2)SC2CCCC2)ccc1c1ccc(cc1)S(=O)(=O)C |
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| Description | NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 30 nM. |
| Target | IC50: 30 nM[1] |
| In Vitro | NMS-873 has antiproliferative effect on a panel of tumor cell lines with IC50 values in the range of 0.08 μM to 2 μM. For HCT116 and HeLa cells, the IC50 values are 0.4 μM and 0.7 μM, respectively. NMS-873 reduces VCP sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873 induces clear, dose-dependent accumulation of poly-Ub proteins and stabilization of cyclin E and Mcl-1 at doses consistent with its antiproliferative IC50 value[1]. |
| Cell Assay | Cells are seeded at 1,600 cells per well in 384-well white clear-bottom plates. Twenty-four hours after seeding, cells are treated with the compounds (eight dilution points, in duplicate, for each compound) and incubated for an additional 72 h at 37°C under a 5% CO2 atmosphere. Cells are then lysed, and the ATP content in each well is determined using a thermostable firefly luciferase-based assay from Promega as a measure of cell viability. IC50 values are calculated using the percentage of growth of treated cells versus the untreated control. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 769.3±70.0 °C at 760 mmHg |
| Flash Point | 419.0±35.7 °C |
| Exact Mass | 520.160278 |
| PSA | 120.65000 |
| LogP | 4.77 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Storage condition | 2-8°C |