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QS-21
| Product Name | QS-21 |
| Price: | Inquiry |
| Catalog No.: | CN07125 |
| CAS No.: | 141256-04-4 |
| Molecular Formula: | C92H148O46 |
| Molecular Weight: | 1990.13 g/mol |
| Purity: | >=98% |
| Type of Compound: | Triterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Platycodon grandiflorum. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CCC(C(OC(=O)CC(CC(C(CC)C)OC1OC(C(C1O)O)CO)O)CC(CC(=O)OC1C(C)OC(C(C1O)OC1OC(C)C(C(C1O)O)OC1OCC(C(C1O)O)OC1OCC(C1O)(O)CO)OC(=O)C12CCC(CC2C2=CCC3C(C2(CC1O)C)(C)CCC1C3(C)CCC(C1(C)C=O)OC1OC(C(=O)O)C(C(C1OC1OC(CO)C(C(C1O)O)O)OC1OCC(C(C1O)O)O)O)(C)C)O)C |
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| Description | QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. |
| Target | NLRP3 inflammasome |
| In Vivo | Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3]. |