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Isodunnianol
| Product Name | Isodunnianol |
| Price: | Inquiry |
| Catalog No.: | CN02991 |
| CAS No.: | 139726-30-0 |
| Molecular Formula: | C27H26O3 |
| Molecular Weight: | 398.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The fruits of Illicium fargesii |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1]. |
| In Vitro | Isodunnianol (10 µM; 6, 24 h) 在 H9C2 细胞中诱导自噬并增加 pAMPK172、pULK1555 的表达，降低 pULK1757、SQSTM2 的表达[1]。 Cell Autophagy Assay[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Induced autophagic. Western Blot Analysis[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Significantly increased the expression of pAMPK172, pULK1555,decreased teh expression of pULK1757, SQSTM2 in a time-dependent manner. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 511.2±50.0 °C at 760 mmHg |
| Flash Point | 263.0±30.1 °C |
| Exact Mass | 398.188202 |
| PSA | 49.69000 |
| LogP | 6.74 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |