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Timosaponin BII
| Product Name | Timosaponin BII |
| Price: | $62 / 20mg |
| Catalog No.: | CN02551 |
| CAS No.: | 136656-07-0 |
| Molecular Formula: | C45H76O19 |
| Molecular Weight: | 920.07 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Anemarrhena asphodeloides Bunge. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OCC1OC(OC2CCC3(C(C2)CCC2C3CCC3(C2CC2C3C(C)C(O2)(O)CCC(COC2OC(CO)C(C(C2O)O)O)C)C)C)C(C(C1O)O)OC1OC(CO)C(C(C1O)O)O |
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| Description | Timosaponin BII is an antioxidant and an anti-inflammatory agent. |
| In Vitro | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1]. |
| In Vivo | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 1033.6±65.0 °C at 760 mmHg |
| Flash Point | 578.9±34.3 °C |
| Exact Mass | 920.498108 |
| PSA | 307.37000 |
| LogP | 0.34 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |