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Lobetyolin
| Product Name | Lobetyolin |
| Price: | $92 / 10mg |
| Catalog No.: | CN06735 |
| CAS No.: | 136085-37-5 |
| Molecular Formula: | C20H28O8 |
| Molecular Weight: | 396.43 g/mol |
| Purity: | >=98% |
| Type of Compound: | Miscellaneous |
| Physical Desc.: | Solid |
| Source: | The roots of Codonopsis pilosula. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OCCC/C=C/C(C(C#CC#C/C=C/C)O)O[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O |
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| Description | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. |
| In Vitro | Lobetyolin is derived from Codonopsis pilosula and has antioxidative effect. MUC5AC gene expression induced by phorbol 12-myristate 13-acetate (PMA) from NCI-H292 cells is inhibited by pretreatment with Lobetyolin, lobetyol or methyl linoleate. Lobetyolin does not affect PMA-induced MUC5AC production from NCI-H292 cells. The amounts of mucin in the cells of Lobetyolin-treated cultures are 100±25%, 487±33%, 524±38%, 411±24%, and 402±45% for control, 10 ng/mL of PMA alone, PMA plus Lobetyolin 1 μM, PMA plus Lobetyolin 10 μM, and PMA plus Lobetyolin 100 μM, respectively[1]. |
| Cell Assay | After 24 hours of serum deprivation, cells are pretreated with Lobetyolin, lobetyol or methyl linoleate (1, 10, and 100 µM), for 30 minutes and then treated with phorbol 12-myristate 13-acetate (PMA; 10 ng/mL) for 24 hours in serum-free RPMI 1640. After 24 hours, the spent media are collected to measure the secretion of MUC5AC protein and cells are lysed with buffer solution containing 20 mM Tris, 0.5% NP-40, 250 mM NaCl, 3 mM EDTA, 3 mM EGTA, and protease inhibitor cocktail and collected to measure the production of MUC5AC protein (in 24-well culture plate)[1]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 698.5±55.0 °C at 760 mmHg |
| Flash Point | 376.2±31.5 °C |
| Exact Mass | 396.178406 |
| PSA | 139.84000 |
| LogP | 2.02 |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |