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Koumine
| Product Name | Koumine |
| Price: | Inquiry |
| Catalog No.: | CN02219 |
| CAS No.: | 1358-76-5 |
| Molecular Formula: | C20H22N2O |
| Molecular Weight: | 306.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The roots of Gelsemium elegans. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | C=C[C@]12CN(C)[C@@H]3[C@@H]4[C@H]1C[C@H](C1=Nc5c([C@]21C3)cccc5)OC4 |
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| Description | Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells[1]. Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities[3], protects against the development of arthritis in Rheumatoid arthritis (RA) animal models[2]. |
| In Vitro | Koumine (0.5, 1 and 2 mg/mL) dose- and time-dependently inhibits the proliferation of MCF-7 cells, with an IC50 of 124 µg/mL at 72 h. Koumine induces apoptosis, causes cell cycle arrest at G2/M phase[1]. Koumine (0.5, 1 and 2 mg/mL) up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in a dose-dependent manner in MCF-7 Cells[1]. Koumine (25, 50, 100, and 200 μM) decreases the protein and mRNA levels of microglia M1 polarization factors in LPS-induced BV2 cells[3]. |
| In Vivo | Koumine is less toxic, with the median lethal dose (LD50) of 300.0 mg/kg on Wistar rats. Koumine (0.6, 3, or 15 mg/kg/per, p.o.) exhibits antirheumatic properties in rats with adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA)[2]. Koumine inhibits the increase in cytokines in joint tissue and TNF-α level in serum at 15 mg/kg, and suppresses the increase in the serum level of IL-1β at 3 and 15 mg/kg[2]. Koumine (0.28, 7 mg/kg, s.c.) significantly reduces neuropathic pain after nerve injury. Koumine suppresses the increased Iba-1 protein level[3]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 436.5±45.0 °C at 760 mmHg |
| Flash Point | 217.8±28.7 °C |
| Exact Mass | 306.173218 |
| PSA | 24.83000 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Storage condition | 2-8C |