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Syringaldehyde
| Product Name | Syringaldehyde |
| Price: | $15 / 20mg |
| Catalog No.: | CN04127 |
| CAS No.: | 134-96-3 |
| Molecular Formula: | C9H10O4 |
| Molecular Weight: | 182.2 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The herbs of Artemisia annua L. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(C=O)cc(c1O)OC |
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| Description | Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis[1]. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities[1]. |
| Target | COX-2:19.2 μM (IC50) |
| In Vitro | Syringaldehyde inhibits COX-2 activity in a dosedependent manner with an IC50 of 3.5 μg/mL[2]. |
| In Vivo | Syringaldehyde exerts anti-hyperglycemic effect in rat model of diabetes induced by streptozotocin. Apart from antioxidant capability, Syringaldehyde also has anti-inflammatory activity as it is found to have inhibitory action on cyclo-oxygenase 2 (COX-2) in mouse macrophage cell line[1]. |
| Animal Admin | Rats[1] Adult male albino wistar rats (weighing 180-220 g) 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; p.o.; for 21 days Adult male albino wistar rats are randomly divided into six groups (n=6), first group serves as control and receives vehicle (orally) for 21 days. Second group is given Syringaldehyde in saline orally at 50 mg/kg for 21 days. Third group receives vehicle for a period of 21 days and then ISO (100 mg/kg, s.c.) on 20th and 21 st day at an interval of 24 h. Fourth group is given Syringaldehyde for 21 days at 12.5 mg/kg, p.o. and ISO on 20th and 21 st day. Fifth group receives Syringaldehyde at concentration of 25 mg/kg, p.o. for 21 days and ISO on 20th and 21 st day. The sixth group is treated with 50 mg/kg of Syringaldehyde for 21 days and ISO on 20th and 21 st day. During the experimental procedure body weight of animals are monitored and on 22nd day, 24 h after second injection of ISO, rats sre sacrificed by cervical decapitation. Note: Body weight of animals belonging to different groups did not differed significantly but heart weight of ISO challenged animals were highly elevated (p ≤ 0.05) than control rats. However, treatment of rats with Syringaldehyde significantly reduced heart weight in dose dependent way. The rats treated with Syringaldehyde alone displayed an insignificant difference from control group. |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 322.1±37.0 °C at 760 mmHg |
| Flash Point | 130.1±20.0 °C |
| Exact Mass | 182.057907 |
| PSA | 55.76000 |
| LogP | 0.86 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |