Home
Products
Go 6983
| Product Name | Go 6983 |
| Price: | Inquiry |
| Catalog No.: | CN00453 |
| CAS No.: | 133053-19-7 |
| Molecular Formula: | C26H26N4O3 |
| Molecular Weight: | 442.51 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1ccc2c(c1)c(cn2CCCN(C)C)C1=C(C(=O)NC1=O)c1c[nH]c2c1cccc2 |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Go 6983 is a pan-PKC inhibitor against for PKCα, PKCβ, PKCγ, PKCδ and PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively. |
| Target | PKCγ:6 nM (IC50) PKCα:7 nM (IC50) PKCβ:7 nM (IC50) PKCδ:10 nM (IC50) PKCζ:60 nM (IC50) PKCμ:20000 nM (IC50) |
| In Vitro | Go 6983 inhibits PKCμ with IC50 of 20 μM, and the pther PKC isoenzymes can be suppressed by Go 6983 with IC50 values from 7 to 60 nM[1]. Go 6983 (100 nM) significantly reduces PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts, and significantly inhibits superoxide release from PMNs by 90 +/- 2% in rat hearts[2]. Go 6983 (200 nM) has a reduced cardioprotective effect compared with the cardioprotective Go 6983 concentrations (50 and 100 nM) despite inhibiting PMN superoxide release by 99%[3]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 709.0±60.0 °C at 760 mmHg |
| Flash Point | 382.6±32.9 °C |
| Exact Mass | 442.200500 |
| PSA | 79.36000 |
| LogP | 3.80 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Storage condition | −20°C |