Home
Products
Vinorelbine Tartrate
| Product Name | Vinorelbine Tartrate |
| Price: | Inquiry |
| Catalog No.: | CN01424 |
| CAS No.: | 125317-39-7 |
| Molecular Formula: | C53H66N4O20 |
| Molecular Weight: | 1079.11 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | The herbs of Catharanthus roseus |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC(=O)C(C(C(=O)O)O)O.OC(=O)C(C(C(=O)O)O)O.COC(=O)[N]1(c2cc3c(cc2OC)N(C2C43CCN3C4C(CC)(C=CC3)C(C2(O)C(=O)OC)OC(=O)C)C)c2ccccc2C2=C1CCC1CN(C2)CC(=C1)CC |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. |
| In Vitro | Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2]. |
| In Vivo | After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4]. |
| Animal Admin | As defined by the study, VRL1 is diluted in 0.9% NaCl to a concentration of 1.5 mg/mL, and given IV over 5 minutes. The intended treatment interval is 7 days for up to 4 treatments. After receiving 4 weekly doses, cats are eligible to continue VRL treatment every 2 weeks. |
| Density | 1.36g/cm3 |
| Exact Mass | 1078.427002 |
| PSA | 363.99000 |
| LogP | 0.44920 |
| Storage condition | 2-8°C |