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Zingerone
| Product Name | Zingerone |
| Price: | $15 / 20mg |
| Catalog No.: | CN04099 |
| CAS No.: | 122-48-5 |
| Molecular Formula: | C11H14O3 |
| Molecular Weight: | 194.23 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenols |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Zingber officinale Rosc. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | COc1cc(CCC(=O)C)ccc1O |
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| Description | Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3]. |
| Target | NF-κB[3] |
| In Vitro | Zingerone is a nontoxic methoxyphenol with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic properties[1]. Zingerone (0-2 mM) decreases neruoblastoma cell survival[3]. Zingerone (0-2 mM) reduces cyclin D1 expression, increases cleavage of caspase-3 and PARP-1 in BE(2)-M17 cells[3]. |
| In Vivo | Zingerone (50, 100 mg/kg, p.o. daily for 21 days) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation in rat[2]. Zingerone (10 mg/kg, i.p.) inhibits tumor progression through mitotic arrest, failure of cell division, and stimulation of apoptosis[3]. |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 323.0±27.0 °C at 760 mmHg |
| Flash Point | 123.7±17.2 °C |
| Exact Mass | 194.094299 |
| PSA | 46.53000 |
| LogP | 0.64 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Storage condition | 2-8°C |