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Isoliquiritin apioside
| Product Name | Isoliquiritin apioside |
| Price: | $234 / 10mg |
| Catalog No.: | CN04837 |
| CAS No.: | 120926-46-7 |
| Molecular Formula: | C26H30O13 |
| Molecular Weight: | 550.5 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Glycyrrhiza uralensis. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OCC1OC(Oc2ccc(cc2)C=CC(=O)c2ccc(cc2O)O)C(C(C1O)O)OC1OCC(C1O)(O)CO |
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| Description | Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1]. |
| Target | MMP9 NF-κB p38 MAPK |
| In Vitro | Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 901.0±65.0 °C at 760 mmHg |
| Flash Point | 301.9±27.8 °C |
| Exact Mass | 550.168640 |
| PSA | 215.83000 |
| LogP | 1.96 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |