Home
Products
Duvelisib (IPI-145)
| Product Name | Duvelisib (IPI-145) |
| Price: | Inquiry |
| Catalog No.: | CN00297 |
| CAS No.: | 1201438-56-3 |
| Molecular Formula: | C22H17ClN6O |
| Molecular Weight: | 416.86 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | Clc1cccc2c1c(=O)n(c(c2)[C@@H](Nc1ncnc2c1nc[nH]2)C)c1ccccc1 |
| Contact us | |
|---|---|
| First Name: | |
| Last Name: | |
| E-mail: | |
| Question: | |
| Description | Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively. |
| Target | p110δ:2.5 nM (IC50) p110γ:27.4 nM (IC50) p110β:85 nM (IC50) p110α:1602 nM (IC50) |
| In Vitro | PI3Kδ and PI3Kγ inhibition with IPI-145 has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells[1]. |
| Density | 1.5±0.1 g/cm3 |
| Exact Mass | 416.115234 |
| PSA | 88.49000 |
| LogP | 4.60 |
| Storage condition | -20°C |