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Salviolone
| Product Name | Salviolone |
| Price: | Inquiry |
| Catalog No.: | CN08634 |
| CAS No.: | 119400-86-1 |
| Molecular Formula: | C18H20O2 |
| Molecular Weight: | 268.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Powder |
| Source: | The roots of Salvia miltiorrhiza |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1]. |
| In Vitro | Salviolone (5-60 μM; 72 hours) 降低 A375 和 MeWo 黑色素瘤细胞系的细胞活力，EC50 值分别为 17 μM 和 22 μM。Salviolone 不影响正常黑素细胞的生长[1]。Salviolone (20 μM; 48-72 hours) 强烈降低 A375 细胞中的 pRb、pCdk2 和细胞周期蛋白 A2、Tyr705-STAT3 磷酸化表达水平。Salviolone 还强烈增加 P21 和 P53 蛋白表达水平。Salviolone 诱导 ERK1/2 和 Akt 磷酸化的持续激活[1]。Salviolone (10-20 μM) 抑制 A375 黑色素瘤细胞系中的 MMP2 明胶酶活性[1]。 Cell Viability Assay[1] Cell Line: A375, MeWo melanoma cells, and NHEM cells Concentration: 5 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM Incubation Time: 72 hours Result: Impaired the viability of melanoma cells without affecting the growth of normal melanocytes. Western Blot Analysis[1] Cell Line: A375 cells Concentration: 20 μM Incubation Time: 48 hours, 72 hours Result: Reduced the expression of the active forms of Cdk2 (pCdk2) and cyclin A2, and the phosphorylation of Rb. |
| Exact Mass | 268.14600 |
| PSA | 37.30000 |
| LogP | 3.82790 |