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Zoledronic Acid
| Product Name | Zoledronic Acid |
| Price: | Inquiry |
| Catalog No.: | CN00132 |
| CAS No.: | 118072-93-8 |
| Molecular Formula: | C5H10N2O7P2 |
| Molecular Weight: | 272.09 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | OP(=O)(C(P(=O)(O)O)(Cn1cncc1)O)O |
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| Description | Zoledronic Acid is a third-generation, nitrogen-containing bisphosphonate, inhibits osteoclast-mediated bone resorption, and also has antitumor activity. |
| In Vitro | Zoledronic Acid induces apoptosis in HGF and HaCaT cells at 0.5 μM, and causes cell death at 1-5 μM[1]. Zoledronic Acid (50, 100 μM) causes dose- and time-dependent apoptosis in CNE-2Z cells after treatment for 24, 48, and 72 h. Zoledronic Acid (50 μM) also increases the level of ROS, which is supposed to mediate Cl- currents activation in CNE-2Z cells. Furthermore, the apoptosis and chloride currents induced by Zoledronic Acid can be blocked by knocking down ClC-3 protein expression[2]. |
| Density | 2.1±0.1 g/cm3 |
| Boiling Point | 764.0±70.0 °C at 760 mmHg |
| Flash Point | 415.8±35.7 °C |
| Exact Mass | 271.996338 |
| PSA | 172.73000 |
| LogP | -2.28 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |