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3'-Methoxypuerarin
| Product Name | 3'-Methoxypuerarin |
| Price: | $131 / 10mg |
| Catalog No.: | CN04851 |
| CAS No.: | 117047-07-1 |
| Molecular Formula: | C22H22O10 |
| Molecular Weight: | 446.4 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Pueraria lobata |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | OC[C@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)O)O)c1c(O)ccc2c1occ(c2=O)c1ccc(c(c1)OC)O |
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| Description | 3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae that shows neuron protection activity. |
| In Vivo | 3'-Methoxypuerarin increases the number of surviving neurons in the hippocampal CA1 region and markedly reduces the number of apoptotic pyramidal neurons after ischemia/reperfusion injury. 3'-Methoxypuerarin can protect hippocampal neurons against I/R injury by inhibiting apoptosis[1]. |
| Animal Admin | Rats[1] Male Wistar rats, weighing 260-320 g are randomly divided into three groups (n = 8 per group). [1] I/R+3'-MOP group: the rats undergo 8 minutes of ischemia and then 3 days of reperfusion. The 3'-Methoxypuerarin (60 mg/kg i.p.) is administrated at the moment of clamping of the carotid arteries. The rats receive daily i.p. injection of 3'-Methoxypuerarin for 3 days. [2] I/R group: the rats undergo 8 minutes of ischemia and 72 h of reperfusion. The same volume of solvent (35% polyethylene glycol solution) is administrated in the same way as 3'-Methoxypuerarin. [3] Control group: the rats undergo a sham operation. Vertebral and carotid arteries are exposed but not occluded. The rats receive a daily i.p. injection of 35% polyethylene glycol solution for 3 days[1]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 706.0±60.0 °C at 760 mmHg |
| Flash Point | 247.5±26.4 °C |
| Exact Mass | 446.121307 |
| PSA | 170.05000 |
| LogP | 1.72 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Storage condition | 2-8℃ |