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Licopyranocoumarin
| Product Name | Licopyranocoumarin |
| Price: | Inquiry |
| Catalog No.: | CN04618 |
| CAS No.: | 117038-80-9 |
| Molecular Formula: | C21H20O7 |
| Molecular Weight: | 384.38 g/mol |
| Purity: | >=98% |
| Type of Compound: | Flavonoids |
| Physical Desc.: | Powder |
| Source: | The roots of Glycyrrhiza uralensis |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1]. |
| Target | CYP3A4:32 μM (IC50) |
| In Vitro | Licopyranocoumarin（0.3-3 μM；48 小时）显着阻断 MPP+ 诱导的神经元 PC12D 细胞死亡和线粒体膜电位消失，这是由 JNK[1] 介导的。 Licopyranocoumarin（0.3-3 μM；36 小时）通过抑制活性氧 (ROS) 的生成来抑制 MPP+ 诱导的 JNK 活化，从而抑制 MPP+ 诱导的神经元 PC12D 细胞死亡[1]。 Cell Viability Assay[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 48 hours Result: Inhibited MPP+-induced cell death. Western Blot Analysis[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 36 hours Result: Attenuated JNK activity induced by MPP+. |
| Density | 1.397g/cm3 |
| Boiling Point | 675.3ºC at 760mmHg |
| Flash Point | 242.9ºC |
| Exact Mass | 384.12100 |
| PSA | 109.36000 |
| LogP | 2.95580 |
| Vapour Pressure | 3.68E-19mmHg at 25°C |