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Dehydromiltirone
| Product Name | Dehydromiltirone |
| Price: | $614 / 5mg |
| Catalog No.: | CN08834 |
| CAS No.: | 116064-77-8 |
| Molecular Formula: | C19H20O2 |
| Molecular Weight: | 282.38 g/mol |
| Purity: | >=98% |
| Type of Compound: | Diterpenoids |
| Physical Desc.: | Red powder |
| Source: | The herb of Salvia miltiorrhiza Bge. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
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| Description | Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2]. |
| In Vitro | Dehydromiltirone (100 μg/mL; 24 h) 抑制 Kupffer 细胞中的 p38 和 NF-κB 信号[1]。 Dehydromiltirone 抑制破骨细胞相关基因的表达，包括 NFATc1、CTSK、c-Fos、Acp5 和 MMP9；以及MAPK信号通路的 P38、ERK 和 JNK 的磷酸化；以及 NF-κB 信号通路中 IκB-α 的降解。Dehydromiltirone 通过降低相关基因的表达来发挥抗破骨细胞生成作用，最终在体外抑制骨吸收[2]。 Western Blot Analysis[1] Cell Line: Kupffer cells Concentration: 100 μg/mL Incubation Time: For 24 h Result: Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels. |
| In Vivo | Dehydromiltirone (50-200 mg/kg，口服；每天；连续五天) 保护肝脏免受 CCl4 诱导的损伤。Dehydromiltirone 可减少促炎细胞因子 TNF-α、IL-1 和 IL-6 的增加，表明它具有减轻肝脏炎症的作用[1]。 Animal Model: Rat model of acute liver injury[1] Dosage: 50 mg/kg, 100 mg/kg, and 200 mg/kg Administration: p.o.; daily; for five consecutive days Result: Protected liver from CCl4-induced damage. |
| Density | 1.116g/cm3 |
| Boiling Point | 423.8ºC at 760mmHg |
| Flash Point | 180.5ºC |
| Exact Mass | 280.14600 |
| PSA | 34.14000 |
| LogP | 4.18590 |
| Vapour Pressure | 2.17E-07mmHg at 25°C |