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Salvianolic acid C
| Product Name | Salvianolic acid C |
| Price: | $92 / 20mg |
| Catalog No.: | CN06959 |
| CAS No.: | 115841-09-3 |
| Molecular Formula: | C26H20O10 |
| Molecular Weight: | 492.44 g/mol |
| Purity: | >=98% |
| Type of Compound: | Phenylpropanoids |
| Physical Desc.: | Powder |
| Source: | The roots of Salvia miltiorrhiza Bge. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: | O=C(O[C@@H](C(=O)O)Cc1ccc(c(c1)O)O)/C=C/c1ccc(c2c1cc(o2)c1ccc(c(c1)O)O)O |
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| Description | Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively. |
| Target | CYP2C8:4.82 μM (Ki) CYP2J2:5.75 μM (Ki) |
| In Vitro | Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with Kis of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively[1]. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF‑κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells[2]. |
| In Vivo | Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus[2]. |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 844.2±65.0 °C at 760 mmHg |
| Flash Point | 464.4±34.3 °C |
| Exact Mass | 492.105652 |
| PSA | 177.89000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Storage condition | 2-8C |