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Clemastanin B
| Product Name | Clemastanin B |
| Price: | Inquiry |
| Catalog No.: | CN02682 |
| CAS No.: | 112747-98-5 |
| Molecular Formula: | C32H44O16 |
| Molecular Weight: | 684.7 g/mol |
| Purity: | >=98% |
| Type of Compound: | Lignans |
| Physical Desc.: | Powder |
| Source: | The roots of Stellera chamaejasme L. |
| Solvent: | DMSO, Pyridine, Methanol, Ethanol, etc. |
| SMILES: |
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| Description | Clemastanin B, a lignin, has potent anti-influenza activities by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. Clemastanin B targets viral endocytosis, uncoating or ribonucleoprotein (RNP) export from the nucleus. Clemastanin B has antioxidant and anti-inflammatory activities[1][2][3]. |
| In Vitro | Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian influenza viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV)[1]. Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells[1]. Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells[1]. Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus[1]. |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 922.6±65.0 °C at 760 mmHg |
| Flash Point | 511.8±34.3 °C |
| Exact Mass | 684.262939 |
| LogP | -2.82 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |