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IWR-1-endo
| Product Name | IWR-1-endo |
| Price: | Inquiry |
| Catalog No.: | CN00480 |
| CAS No.: | 1127442-82-3 |
| Molecular Formula: | C25H19N3O3 |
| Molecular Weight: | 409.44 g/mol |
| Purity: | >=98% |
| Type of Compound: | Alkaloids |
| Physical Desc.: | Powder |
| Source: | |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | O=C1N(c2ccc(cc2)C(=O)Nc2cccc3c2nccc3)C(=O)C2C1C1C=CC2C1 |
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| Description | IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin signaling pathway. |
| Target | IC50: 180 nM (Wnt) |
| In Vitro | Both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects in vitro. IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly[1]. IWR-1 (10 μM) induces stabilization of β-catenin disruption complex. IWR-1 (10 μM) is added to the medium together with MIF, the size of cell colonies is extremely decreased, and that indicates the promoting effect of MIF on NSPC proliferation is inhibited by IWR-1 in any MIF concentration group. 2, 5 and 10 μM of IWR-1 significantly inhibits the proliferation of NSPC dose-dependently. IWR-1 inhibites the promoting effect of MIF on NSPC differentiation to neuron lineage[2]. IWR-1 treatment in the presence of maximal stimulatory dose of FSH (0.5 ng/mL) results in a dose dependent inhibition of the stimulatory effect of FSH with > 75% inhibition observed at the maximal inhibitory dose of IWR-1 (1 µM). IWR-1 treatment partially reverses the FSH-induced inhibition of granulosa cell CARTPT mRNA expression[3]. |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 643.9±55.0 °C at 760 mmHg |
| Flash Point | 343.2±31.5 °C |
| Exact Mass | 409.142639 |
| PSA | 79.37000 |
| LogP | 2.65 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Storage condition | Store at RT |