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Cinobufotalin
| Product Name | Cinobufotalin |
| Price: | $146 / 10mg |
| Catalog No.: | CN02493 |
| CAS No.: | 1108-68-5 |
| Molecular Formula: | C26H34O7 |
| Molecular Weight: | 458.54 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The glandular body of Bufo bufo gargarizans Cantor. |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: |
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| Description | Cinobufotalin is one of the bufadienolides prepared from toad venom; has anticancer activity.IC50 value:Target:in vitro: Cinobufotalin(CB) caused significant DNA fragmentation, decrease of MMP, and an increase in the intracellular Ca(2+) ion and ROS production. In addition, CB induced upregulation of Fas protein, proteolytic activation of cytochrome c, caspase-2, -3, -8 and -9 together with the activation of Bid and Bax [1]. cinobufotalin displayed considerable cytotoxicity against lung cancer cells (A549, H460 and HTB-58 lines) without inducing significant cell apoptosis. cinobufotalin mainly induces Cyp-D-dependent non-apoptotic death in cultured lung cancer cells [2]. cinobufotalin (at nmol/L) significantly inhibited HCC cell growth and survival while inducing considerable cell apoptosis. Further, cinobufotalin inhibited sphingosine kinase 1 (SphK1) activity and induced pro-apoptotic ceramide production. cinobufotalin inactivated Akt-S6K1 signaling in HepG2 cells, which was again inhibited by ceramide synthase-1 shRNA-depletion [3].in vivo: Using a mice xenograft model, we found that cinobufotalin inhibited A549 lung cancer cell growth in vivo [2]. |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 627.3±55.0 °C at 760 mmHg |
| Flash Point | 210.7±25.0 °C |
| Exact Mass | 458.230438 |
| PSA | 109.50000 |
| LogP | 0.79 |
| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
| Storage condition | 2-8°C |