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Taccalonolide A
| Product Name | Taccalonolide A |
| Price: | $293 / 10mg |
| Catalog No.: | CN02441 |
| CAS No.: | 108885-68-3 |
| Molecular Formula: | C36H46O14 |
| Molecular Weight: | 702.74 g/mol |
| Purity: | >=98% |
| Type of Compound: | Steroids |
| Physical Desc.: | Powder |
| Source: | The rhizomes of Schizocapsa plantaginea Hance |
| Solvent: | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| SMILES: | CC(=O)O[C@H]1[C@H]2[C@@H]([C@@H](O)C(=O)[C@@H]3[C@]2(C)[C@@H](OC(=O)C)[C@H]2O[C@H]2C3)[C@H]2[C@@]([C@H]1OC(=O)C)(C)[C@H]1[C@H](C)C=C3[C@]([C@@H]1[C@@H]2OC(=O)C)(C)[C@](C)(O)C(=O)O3 |
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| Description | Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3]. |
| Target | microtubule[1] |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 776.8±60.0 °C at 760 mmHg |
| Flash Point | 237.8±26.4 °C |
| Exact Mass | 702.288757 |
| PSA | 201.56000 |
| LogP | 2.49 |
| Vapour Pressure | 0.0±6.1 mmHg at 25°C |
| Storage condition | 2-8℃ |